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Use of celecoxib may blunt the CV effects of several therapeutic agents used to treat these medical conditions e. In the CLASS studythe Kaplan-Meier cumulative rates at 9 months of peripheral edema in patients on Celebrex 400 mg twice daily 4-fold and 2-fold the recommended OA and RA doses, respectively, ibuprofen 800 mg three times daily and diclofenac 75 mg twice daily were 4. Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion.
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